Leonurus sibiricus herb extract suppresses oxidative stress and ameliorates hypercholesterolemia in C57BL/6 mice and TNF-alpha induced expression of adhesion molecules and lectin-like oxidized LDL receptor-1 in human umbilical vein endothelial cells

Biosci Biotechnol Biochem. 2010;74(2):279-84. doi: 10.1271/bbb.90582. Epub 2010 Feb 7.

Abstract

In Leonurus sibiricus herb extract (LHE)-supplemented animals, plasma cholesterol decreased and high-density lipoprotein-cholesterol increased, resulting in a lowered atherogenic index. The plasma trolox equivalent antioxidant capacity, levels of hepatic thiobarbituric acid-reactive substances, and protein carbonyl values decreased significantly in LHE-supplemented mice (p<0.05), whereas the hepatic antioxidant indicators were all significantly elevated (p<0.05). In human umbilical vein endothelial cells stimulated with tumor necrosis factor alpha, LHE significantly suppressed intracellular reactive oxygen species, LOX-1, and adhesion molecules. LHE supplementation may modulate the lipoprotein composition and attenuate oxidative stress by elevated antioxidant processes, thus suppressing the activation of inflammatory mediators. This is a possible mechanism of the anti-atherogenic effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Adhesion Molecules / metabolism*
  • Cells, Cultured
  • Endothelial Cells / drug effects*
  • Female
  • Humans
  • Hypercholesterolemia / metabolism*
  • Lectins / metabolism
  • Leonurus / metabolism*
  • Mice
  • Oxidative Stress / drug effects*
  • Plant Extracts / pharmacology*
  • Receptors, Oxidized LDL / metabolism*
  • Tumor Necrosis Factor-alpha / metabolism*
  • Umbilical Veins / cytology

Substances

  • Cell Adhesion Molecules
  • Lectins
  • Plant Extracts
  • Receptors, Oxidized LDL
  • Tumor Necrosis Factor-alpha