Common Variants Near TERC Are Associated With Mean Telomere Length

Nat Genet. 2010 Mar;42(3):197-9. doi: 10.1038/ng.532. Epub 2010 Feb 7.

Abstract

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aging / genetics
  • Chromosomes, Human, Pair 3
  • Cohort Studies
  • Gene Frequency
  • Genome-Wide Association Study
  • Humans
  • Meta-Analysis as Topic
  • Polymorphism, Single Nucleotide* / physiology
  • Quantitative Trait Loci
  • RNA / genetics*
  • RNA / physiology
  • Telomerase / genetics*
  • Telomerase / physiology
  • Telomere / genetics*
  • Telomere / metabolism
  • Time Factors

Substances

  • telomerase RNA
  • RNA
  • Telomerase