Genome-wide association study of hematological and biochemical traits in a Japanese population

Nat Genet. 2010 Mar;42(3):210-5. doi: 10.1038/ng.531. Epub 2010 Feb 7.

Abstract

We report genome-wide association studies for hematological and biochemical traits from approximately 14,700 Japanese individuals. We identified 60 associations for 8 hematological traits and 29 associations for 12 biochemical traits at genome-wide significance levels (P < 5 x 10(-8)). Of these, 46 associations were new to this study and 43 replicated previous reports. We compared these associated loci with those reported in similar GWAS in European populations. When the minor allele frequency was >10% in the Japanese population, 32 (94.1%) and 31 (91.2%) of the 34 hematological loci previously reported to be associated in a European population were replicated with P-values less than 0.05 and 0.01, respectively, and 31 (73.8%) and 27 (64.3%) of the 42 European biochemical loci were replicated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian Continental Ancestry Group / genetics*
  • Biomarkers / analysis
  • Biomarkers / blood*
  • Blood Cell Count
  • Blood Chemical Analysis
  • Cohort Studies
  • Erythrocytes / cytology
  • Erythrocytes / pathology
  • Gene Frequency
  • Genetics, Population
  • Genome-Wide Association Study*
  • Hematologic Diseases / blood
  • Hematologic Diseases / genetics
  • Hematologic Diseases / pathology
  • Hematologic Tests
  • Humans
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci*
  • Uric Acid / blood

Substances

  • Biomarkers
  • Uric Acid