Chemical phylogenetics of histone deacetylases

Nat Chem Biol. 2010 Mar;6(3):238-243. doi: 10.1038/nchembio.313. Epub 2010 Feb 7.


The broad study of histone deacetylases in chemistry, biology and medicine relies on tool compounds to derive mechanistic insights. A phylogenetic analysis of class I and II histone deacetylases (HDACs) as targets of a comprehensive, structurally diverse panel of inhibitors revealed unexpected isoform selectivity even among compounds widely perceived as nonselective. The synthesis and study of a focused library of cinnamic hydroxamates allowed the identification of, to our knowledge, the first nonselective HDAC inhibitor. These data will guide a more informed use of HDAC inhibitors as chemical probes and therapeutic agents.

Associated data

  • PubChem-Substance/87226482
  • PubChem-Substance/87226502
  • PubChem-Substance/87226493
  • PubChem-Substance/87226494
  • PubChem-Substance/87226483
  • PubChem-Substance/87226495
  • PubChem-Substance/87226395
  • PubChem-Substance/87226496
  • PubChem-Substance/87226497
  • PubChem-Substance/87226498
  • PubChem-Substance/87226499
  • PubChem-Substance/87226484
  • PubChem-Substance/87226485
  • PubChem-Substance/87226486
  • PubChem-Substance/87226487
  • PubChem-Substance/87226488
  • PubChem-Substance/87226492
  • PubChem-Substance/87226489
  • PubChem-Substance/87226500
  • PubChem-Substance/87226490
  • PubChem-Substance/87226501
  • PubChem-Substance/87226491