Failure to Detect Borna Disease Virus Antibody and RNA From Peripheral Blood Mononuclear Cells of Psychiatric Patients

Psychiatry Investig. 2009 Dec;6(4):306-12. doi: 10.4306/pi.2009.6.4.306. Epub 2009 Nov 5.


Objective: Borna disease virus (BDV) is a highly neurotropic agent causing various neuropsychiatric symptoms in animals. Over the past two decades, it has been suggested that BDV might be associated with human psychiatric diseases. We aimed to investigate whether BDV is associated with psychiatric patients in Korea.

Methods: We recruited 60 normal controls and 198 psychiatric patients (98 patients with depressive disorder, 60 with schizophrenia, and 40 with bipolar disorder). We used an indirect immunofluorescence antibody (IFA) test for the BDV antibody and a real-time reverse transcriptase polymerase chain reaction (rRT-PCR) assay for p24 and p40 RNA from peripheral blood mononuclear cells (PBMCs).

Results: Neither the BDV antibody nor p24, p40 RNA was detected in controls and patients groups.

Conclusion: Our results suggest that BDV might not be associated with psychiatric patients in Korea.

Keywords: Borna disease virus; Peripheral blood mononuclear cell; Psychiatric disorders; Real-time reverse transcriptase polymerase chain reaction.