Influence of selenium on innate immune response in kids

Folia Microbiol (Praha). 2009 Nov;54(6):545-8. doi: 10.1007/s12223-009-0079-5. Epub 2010 Feb 7.

Abstract

The effect is described of selenium supplemented in an inorganic and organic form on the innate immune response of goats. Though the phagocytic activity (as a marker of the immune function) was found to be lower in organic-Se-treated group than in control (54.5 +/- 4.32 vs. 60.2 +/- 9.15 %), it did not generally exhibit any significant differences; similarly, no differences were found in the phagocytic index. The production of reactive oxygen species (ROS) was determined using the luminol-enhanced chemiluminescence (CL) (estimated as peak CL, integral CL and a peak time after addition of calcium ionophore A23187, opsonised zymosan (OZP) and phorbol-12-myristate-13-acetate as effectors. A significant ROS increase reflected in integral CL and a peak time was found in the inorganic-Se-treated group when OZP was used as activator; other parameters did not exhibit significant changes. The supplementation of Se in inorganic form can thus be seen to influence positively the innate immune system of kids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Goats
  • Immunity, Innate / drug effects*
  • Immunologic Factors / administration & dosage*
  • Inorganic Chemicals / administration & dosage
  • Male
  • Organic Chemicals / administration & dosage
  • Phagocytosis / drug effects
  • Reactive Oxygen Species / metabolism
  • Selenium / administration & dosage*

Substances

  • Immunologic Factors
  • Inorganic Chemicals
  • Organic Chemicals
  • Reactive Oxygen Species
  • Selenium