Abstract
The stereoselective synthesis of the monocyclic peloruside A analogue 4 has been achieved, following a new efficient approach for the introduction of the side chain, involving a late-stage addition of vinyl lithium species 7a to aldehyde 8. Further key steps are a highly diastereoselective allyltitanation reaction and a RCM-based macrocyclization.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Cyclization
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Lactones / chemical synthesis*
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Lactones / chemistry*
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Stereoisomerism
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Substrate Specificity
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Lactones
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peloruside A