Abstract
Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amphotericin B / pharmacology
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Antimalarials / chemistry
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Antimalarials / isolation & purification*
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Antimalarials / pharmacology*
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Candida albicans / drug effects
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Drug Resistance / drug effects
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Drug Screening Assays, Antitumor
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Enterococcus faecium / drug effects
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Female
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Fiji
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Humans
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology*
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Male
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Plasmodium falciparum / drug effects
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Rhodophyta / chemistry*
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Vancomycin / pharmacology
Substances
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Antimalarials
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Diterpenes
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Macrolides
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Vancomycin
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Amphotericin B