The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse

Am J Drug Alcohol Abuse. 2010 Jan;36(1):46-51. doi: 10.3109/00952990903544844.

Abstract

Background: Bupropion's efficacy for smoking cessation in pregnant women is unknown.

Objectives: To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication.

Methods: Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups.

Results and conclusions: Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day].

Scientific significance: Data support continued study of bupropion in depressed pregnant substance-dependent smokers.

Publication types

  • Controlled Clinical Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Bupropion / therapeutic use*
  • Citalopram / therapeutic use*
  • Depressive Disorder, Major / complications
  • Depressive Disorder, Major / drug therapy*
  • Diagnosis, Dual (Psychiatry)
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Pregnant Women / psychology*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Smoking / drug therapy*
  • Smoking Cessation / psychology*
  • Substance-Related Disorders / complications
  • Substance-Related Disorders / drug therapy*
  • Treatment Outcome

Substances

  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors
  • Bupropion
  • Citalopram