Fermented Maesil (Prunus mume) with probiotics inhibits development of atopic dermatitis-like skin lesions in NC/Nga mice

Vet Dermatol. 2010 Apr;21(2):184-91. doi: 10.1111/j.1365-3164.2009.00796.x. Epub 2010 Feb 5.


Maesil (Prunus mume Siebold & Zucc.), a potential source of free radical scavengers and inhibitor of pro-inflammatory mediators, is used in traditional Korean medical preparations as a remedy for skin disorders as have probiotics. The action of a probiotic fermented Maesil preparation on the development of atopic dermatitis (AD)-like skin lesions was determined in a NC/Nga mouse model as an initial step towards the development of a therapeutic feed supplement for use in dogs. Continuous ingestion of the experimental feed markedly inhibited the development of the AD-like skin lesions, as evidenced by a marked decrease in skin signs and reduced inflammation within the skin lesions. Efficacy was confirmed by significant decreases in eosinophil ratio and serum IgE concentration, and a reduction in the number of Staphylococcus aureus recovered from the ear. Relative mRNA expression levels of IL-4, interferon-gamma and tumour necrosis factor-alpha in the spleens of the experimental animals were also decreased and there was an increased serum concentration of IL-10 with a concurrent decreased IL-4 concentration in comparison to a control group. Taken together, the results indicate that some component(s) of fermented Maesil have the ability to suppress the development of AD-like skin lesions, possibly by stimulation of IL-10. Beneficial effects of fermented Maesil may thus be expected in dogs with AD, although this and the nature of the active pathway remain to be explored.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Cytokines / blood
  • Dermatitis, Atopic / blood
  • Dermatitis, Atopic / chemically induced
  • Dermatitis, Atopic / prevention & control*
  • Dinitrochlorobenzene / toxicity
  • Dogs
  • Female
  • Fermentation
  • Fruit
  • Immunoglobulin E / blood
  • Mice
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Probiotics / pharmacology*
  • Prunus / chemistry*
  • Specific Pathogen-Free Organisms
  • Staphylococcus aureus / drug effects
  • Time Factors


  • Cytokines
  • Dinitrochlorobenzene
  • Plant Extracts
  • Immunoglobulin E