USP10: friend and foe

Cell. 2010 Feb 5;140(3):308-10. doi: 10.1016/j.cell.2010.01.034.


The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • DNA Repair*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Tumor Suppressor Protein p53 / metabolism
  • Ubiquitin Thiolesterase / metabolism*
  • Ubiquitination


  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • USP10 protein, human
  • Ubiquitin Thiolesterase