Short RNAs: how big is this iceberg?

Curr Biol. 2010 Feb 9;20(3):R110-3. doi: 10.1016/j.cub.2009.12.036.


Recent studies have reported the identification of piwi-associated RNAs (piRNAs) in Drosophila somatic cells. Interestingly, these piRNAs derive from the 3' untranslated regions of a subset of transcribed protein-coding genes and, experimentation suggests, might control the expression of other protein-coding transcripts. Studies of additional organisms support the new pathway's presence across animals.

MeSH terms

  • 3' Untranslated Regions
  • Animals
  • Cell Line
  • Drosophila / genetics
  • Drosophila / metabolism
  • Female
  • Models, Biological
  • Ovary / cytology
  • Ovary / metabolism
  • RNA, Small Interfering / genetics*
  • RNA, Small Interfering / metabolism*


  • 3' Untranslated Regions
  • RNA, Small Interfering