Transcription control of early B cell differentiation

Curr Opin Immunol. 2010 Apr;22(2):161-7. doi: 10.1016/j.coi.2010.01.010. Epub 2010 Feb 9.


Differentiation of B lymphocytes involves the step-wise acquisition of a specialized phenotype that depends on the expression of lineage-specific genes and the repression of genes characteristic of multipotent progenitors and alternate lineages. The early steps of B lineage specification and commitment are, partly, controlled by the well-characterized transcription factors Ikaros, Pu.1, E2A, early B cell factor-1, and Pax5 that act in a complex regulatory network. However, our understanding of B cell differentiation is far from complete. Recent work has shed light on the mechanisms by which transcription factors implement cell type-specific gene expression patterns and epigenetic changes in chromatin that allow for B lineage specification and commitment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology*
  • Cell Differentiation / genetics*
  • Cell Differentiation / immunology
  • Cell Lineage / genetics*
  • Cell Lineage / immunology
  • Epigenesis, Genetic / immunology
  • Gene Expression Regulation, Developmental
  • Gene Regulatory Networks
  • Humans
  • Transcription Factors / immunology*
  • Transcriptional Activation / immunology*


  • Transcription Factors