The Cvt pathway as a model for selective autophagy

FEBS Lett. 2010 Apr 2;584(7):1359-66. doi: 10.1016/j.febslet.2010.02.013. Epub 2010 Feb 8.


Autophagy is a highly conserved, ubiquitous process that is responsible for the degradation of cytosolic components in response to starvation. Autophagy is generally considered to be non-selective; however, there are selective types of autophagy that use receptor and adaptor proteins to specifically isolate a cargo. One type of selective autophagy in yeast is the cytoplasm to vacuole targeting (Cvt) pathway. The Cvt pathway is responsible for the delivery of the hydrolase aminopeptidase I to the vacuole; as such, it is the only known biosynthetic pathway that utilizes the core machinery of autophagy. Nonetheless, it serves as a model for the study of selective autophagy in other organisms.

Publication types

  • Review

MeSH terms

  • Autophagy*
  • Models, Biological*
  • Saccharomyces cerevisiae / cytology*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism
  • Signal Transduction*


  • Saccharomyces cerevisiae Proteins