Neuroscience: Lack of inhibition leads to abuse

Nature. 2010 Feb 11;463(7282):743-4. doi: 10.1038/463743a.

Abstract

Chronic drug use can lead to addiction, which is initiated by specific brain circuits. The mystery of how one class of drugs, the benzodiazepines, affects activity in this circuitry has finally been solved.

Publication types

  • Comment
  • News

MeSH terms

  • Animals
  • Behavior, Addictive / chemically induced*
  • Behavior, Addictive / metabolism
  • Behavior, Addictive / physiopathology*
  • Benzodiazepines / administration & dosage
  • Benzodiazepines / adverse effects*
  • Benzodiazepines / metabolism
  • Benzodiazepines / pharmacology*
  • Dopamine / metabolism
  • GABA-A Receptor Antagonists
  • Glutamic Acid / metabolism
  • Interneurons / drug effects*
  • Interneurons / metabolism*
  • Mice
  • Models, Biological
  • Morphine / pharmacology
  • Receptors, AMPA / metabolism
  • Receptors, GABA-A / deficiency
  • Receptors, GABA-A / genetics
  • Receptors, GABA-A / metabolism
  • Ventral Tegmental Area / cytology
  • Ventral Tegmental Area / drug effects
  • Ventral Tegmental Area / metabolism

Substances

  • GABA-A Receptor Antagonists
  • Gabra1 protein, mouse
  • Receptors, AMPA
  • Receptors, GABA-A
  • Benzodiazepines
  • Glutamic Acid
  • Morphine
  • Dopamine