Alternative splicing of SMADs in differentiation and tissue homeostasis

Dev Growth Differ. 2010 May;52(4):335-42. doi: 10.1111/j.1440-169X.2009.01163.x. Epub 2010 Apr 5.


Tissue-specific alternate splicing is an important means of regulating gene expression during development. The effector proteins for the transforming growth factor-beta signaling pathway, the SMADs, encode distinct isoforms generated via alternate splicing, which appear to have distinct tissue-specific expression profiles and functions. Here, we discuss the roles of various SMAD isoforms, and the consequences of mis-regulation of SMAD splicing in development and tissue homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Cell Differentiation / genetics*
  • Gene Expression Profiling
  • Hematopoietic Stem Cells / metabolism
  • Homeostasis / genetics*
  • Humans
  • Protein Isoforms / genetics
  • Smad Proteins / genetics*
  • Smad5 Protein / genetics


  • Protein Isoforms
  • Smad Proteins
  • Smad5 Protein