Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis

J Clin Periodontol. 2010 Mar;37(3):255-65. doi: 10.1111/j.1600-051X.2009.01530.x.


Aim: A systematic review and a meta-analysis were conducted in order to investigate the potential association of Fcgamma receptor (FcgammaR) polymorphisms with susceptibility to aggressive and chronic periodontal disease.

Materials and methods: A database search yielded a total of 17 studies involving 1685 cases and 1570 controls. Three polymorphisms were included in the meta-analysis: FcgammaRIIA H131R (rs1801274), FcgammaRIIIA F158V (rs396991) and FcgammaRIIIB NA1/NA2. Random-effect models were used in the analysis. Odds ratios (ORs) along with their 95% confidence intervals (CIs) were computed to compare the distribution of alleles and genotypes between cases and controls.

Results and conclusions: The FcgammaRIIIB NA1/NA2 polymorphism was associated with both aggressive (per-allele OR 2.005, 95% CI: 1.044, 3.851) and chronic periodontitis (recessive contrast NA2NA2 versus NA1NA1+NA1NA2 OR 1.397, 95% CI: 1.039, 1.878). The analysis showed weak evidence for association between the FcgammaRIIA H131R polymorphism and aggressive periodontitis in Asians (R versus H allele OR 1.579, 95% CI: 1.025, 2.432). On the contrary, no relationship was identified between FcgammaRIIIA F158V and periodontal disease. Accumulating evidence from basic research makes the suggested association between FcgammaRIIIB NA1/NA2 polymorphism and periodontitis biologically plausible. Further research, however, is needed in order to assess possible gene-gene or gene-environment interactions (i.e. with smoking).

Publication types

  • Meta-Analysis
  • Review
  • Systematic Review

MeSH terms

  • Aggressive Periodontitis / genetics*
  • Case-Control Studies
  • Chronic Periodontitis / genetics*
  • Humans
  • Models, Genetic
  • Odds Ratio
  • Polymorphism, Genetic / genetics*
  • Receptors, IgG / genetics*


  • Receptors, IgG