Two-component signaling circuit structure and properties

Curr Opin Microbiol. 2010 Apr;13(2):184-9. doi: 10.1016/j.mib.2010.01.009. Epub 2010 Feb 10.


Various modeling and experimental studies have analyzed the reactions, interconnections, and motifs in two-component systems, with an eye toward understanding their physiological implications and the differences between alternative designs. Examples where recent progress has been made include aspects of autoregulation, signal integration in branched pathways, cross-talk suppression, and cross-regulation via connector proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacterial Physiological Phenomena
  • Bacterial Proteins* / chemistry
  • Bacterial Proteins* / genetics
  • Bacterial Proteins* / metabolism
  • Gene Expression Regulation, Bacterial*
  • Phosphoric Monoester Hydrolases / chemistry
  • Phosphoric Monoester Hydrolases / genetics
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphorylation
  • Signal Transduction*
  • Spores, Bacterial / physiology


  • Bacterial Proteins
  • Phosphoric Monoester Hydrolases