Manipulation of a central auditory representation shapes learned vocal output

Neuron. 2010 Jan 14;65(1):122-34. doi: 10.1016/j.neuron.2009.12.008.

Abstract

Learned vocalizations depend on the ear's ability to monitor and ultimately instruct the voice. Where is auditory feedback processed in the brain, and how does it modify motor networks for learned vocalizations? Here we addressed these questions using singing-triggered microstimulation and chronic recording methods in the singing zebra finch, a small songbird that relies on auditory feedback to learn and maintain its species-typical vocalizations. Manipulating the singing-related activity of feedback-sensitive thalamic neurons subsequently triggered vocal plasticity, constraining the central pathway and functional mechanisms through which feedback-related information shapes vocalization.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Animals
  • Auditory Pathways / anatomy & histology
  • Auditory Pathways / physiology*
  • Auditory Perception / physiology*
  • Electrophysiology
  • Feedback
  • Finches / anatomy & histology
  • Finches / physiology*
  • Learning / physiology*
  • Male
  • Neuronal Plasticity / physiology
  • Thalamus / cytology
  • Thalamus / physiology
  • Vocalization, Animal / physiology*