MicroRNAs in mouse development and disease

Semin Cell Dev Biol. 2010 Sep;21(7):774-80. doi: 10.1016/j.semcdb.2010.02.004. Epub 2010 Feb 10.


MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we review the involvement of microRNAs in mouse development and disease, with particular reference to deafness as an example.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cochlea / cytology
  • Cochlea / embryology
  • Cochlea / metabolism
  • Deafness / genetics*
  • Disease / genetics
  • Humans
  • Mice
  • MicroRNAs / genetics*
  • Mutagenesis


  • MicroRNAs
  • Mirn96 microRNA, mouse