Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
- PMID: 20153103
- DOI: 10.1016/j.canlet.2010.01.029
Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration
Abstract
Cucurbitacin B is an anti-cancer drug candidate and its efficacy has been demonstrated in hepatocellular carcinoma (HCC). To explore its mechanism against HCC, BEL-7402 cells were treated with cucurbitacin B in vitro. Treatment with cucurbitacin B induced S phase arrest and apoptosis. The growth inhibition effect was associated with cyclin D1 and cdc-2 down regulations. Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibited c-Raf activation without affecting STAT3 phosphorylation. Moreover, in vivo study demonstrated that cucurbitacin B is effective against BEL-7402 xenograft when administrated orally.
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Similar articles
-
Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B.Cancer Chemother Pharmacol. 2009 Mar;63(4):635-42. doi: 10.1007/s00280-008-0780-0. Epub 2008 Jun 3. Cancer Chemother Pharmacol. 2009. PMID: 18521604
-
STAT3 inhibitor, cucurbitacin I, is a novel therapeutic agent for osteosarcoma.Int J Oncol. 2016 Dec;49(6):2275-2284. doi: 10.3892/ijo.2016.3757. Epub 2016 Nov 3. Int J Oncol. 2016. PMID: 27840900 Free PMC article.
-
[Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 May;22(9):403-7. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008. PMID: 18652313 Chinese.
-
Sensitizing to apoptosis--sharpening the medical sword.J Hepatol. 2004 Feb;40(2):335-6. doi: 10.1016/j.jhep.2003.11.022. J Hepatol. 2004. PMID: 14739108 Review. No abstract available.
-
Cucurbitacin IIa: A review of phytochemistry and pharmacology.Phytother Res. 2021 Aug;35(8):4155-4170. doi: 10.1002/ptr.7077. Epub 2021 Mar 16. Phytother Res. 2021. PMID: 33724593 Review.
Cited by
-
In Vitro Anticancer Potential of Jasione montana and Its Main Components against Human Amelanotic Melanoma Cells.Int J Mol Sci. 2021 Mar 25;22(7):3345. doi: 10.3390/ijms22073345. Int J Mol Sci. 2021. PMID: 33805898 Free PMC article.
-
Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells.Evid Based Complement Alternat Med. 2012;2012:957568. doi: 10.1155/2012/957568. Epub 2012 Jun 20. Evid Based Complement Alternat Med. 2012. PMID: 22778780 Free PMC article.
-
Efficient extraction of cucurbitacins from Diplocyclos palmatus (L.) C. Jeffrey: Optimization using response surface methodology, extraction methods and study of some important bioactivities.Sci Rep. 2020 Feb 7;10(1):2109. doi: 10.1038/s41598-020-58924-5. Sci Rep. 2020. PMID: 32034276 Free PMC article.
-
Silkworm Pupa Protein Hydrolysate Induces Mitochondria-Dependent Apoptosis and S Phase Cell Cycle Arrest in Human Gastric Cancer SGC-7901 Cells.Int J Mol Sci. 2018 Mar 28;19(4):1013. doi: 10.3390/ijms19041013. Int J Mol Sci. 2018. PMID: 29597296 Free PMC article.
-
HPTLC Analysis of Bioactivity Guided Anticancer Enriched Fraction of Hydroalcoholic Extract of Picrorhiza kurroa.Biomed Res Int. 2015;2015:513875. doi: 10.1155/2015/513875. Epub 2015 Oct 18. Biomed Res Int. 2015. PMID: 26557675 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
