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Clinical Trial
. 2010 Mar 30;181(3):174-82.
doi: 10.1016/j.pscychresns.2009.11.003. Epub 2010 Feb 12.

Working Memory fMRI Activation in Cocaine-Dependent Subjects: Association With Treatment Response

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Free PMC article
Clinical Trial

Working Memory fMRI Activation in Cocaine-Dependent Subjects: Association With Treatment Response

F Gerard Moeller et al. Psychiatry Res. .
Free PMC article

Abstract

Functional magnetic resonance imaging (fMRI) studies of early abstinence cocaine users offer information about the state of the brain when most cocaine users seek treatment. This study examined the relationship between pretreatment brain function and subsequent treatment response in 19 treatment-seeking early abstinence cocaine-dependent (CD) subjects. These subjects and 14 non-drug-using control subjects underwent fMRI while performing a working memory task with three levels of difficulty. CD subjects were then randomized to treatment studies. Results showed CD subjects had significantly lower (random effects, corrected for multiple comparisons) brain activation in caudate, putamen, cingulate gyrus, middle and superior frontal gyri, inferior frontal gyrus pars triangularis and pars opercularis, precentral gyrus, and thalamus compared with non-drug-using controls. Within CD subjects, thalamic activation significantly correlated with treatment response. This study shows CD subjects in early abstinence have alterations of brain function in frontal, striatal, and thalamic brain regions known to be part of a circuit associated with motor control, reward, and cognition. Subjects with pretreatment thalamic deactivation showed the poorest treatment response, possibly related to thalamic involvement in mesocortical and mesolimbic dopamine projections.

Figures

Figure 1
Figure 1
Brain regions, where cocaine dependent subjects showed significantly lower BOLD activation in DMT during the 7-digit condition compared to normal controls, are overlayed in color on axial slices of the MNI single-subject template brain. The number below each slice indicates slice location (mm) of MNI Z coordinate. Scale on color bar represents t values.
Figure 2
Figure 2
TES scores in 12 CD subjects who showed a pretreatment BOLD deactivation relative to NORM subjects in the thalamic cluster (Cluster 3 in Table 3) and 7 subjects who showed BOLD activation in the thalamic cluster. Error bars indicate standard deviation.

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