Scaffold-free cell delivery for use in regenerative medicine

Adv Drug Deliv Rev. 2010 Jun 15;62(7-8):753-64. doi: 10.1016/j.addr.2010.02.003. Epub 2010 Feb 11.


The development of cell-based therapies for diseased tissues is one of the most promising research directions in regenerative medicine. Cell-delivery methods are an essential part of cell therapy concepts. Therapies with the potential to become clinical routine will only be possible if these methods ensure efficient engraftment and therapeutically-relevant number of cells survive. Here we provide an overview of three different scaffold-free cell-delivery concepts: (i) single cell delivery, (ii) cell sheet engineering and (iii) microtissue technology.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Culture Techniques
  • Cell Survival
  • Cell Transplantation / methods*
  • Humans
  • Regenerative Medicine / methods*
  • Stem Cell Transplantation / methods
  • Tissue Engineering / methods*