Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats

Behav Brain Res. 2010 Jun 26;210(1):140-2. doi: 10.1016/j.bbr.2010.02.019. Epub 2010 Feb 12.


The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Hydroxyindoleacetic Acid / metabolism*
  • Male
  • Maze Learning / physiology
  • Memory Disorders / etiology
  • Memory Disorders / metabolism*
  • Neuropsychological Tests
  • Pyrithiamine
  • Rats
  • Rats, Wistar
  • Serotonin / metabolism*
  • Space Perception / physiology*
  • Thalamus / metabolism*
  • Thiamine Deficiency / chemically induced
  • Thiamine Deficiency / complications
  • Thiamine Deficiency / metabolism*
  • Time Factors


  • Serotonin
  • Hydroxyindoleacetic Acid
  • Pyrithiamine