Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study

Fertil Steril. 2010 Sep;94(4):1544-1547. doi: 10.1016/j.fertnstert.2009.12.060. Epub 2010 Feb 13.


This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimüllerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Mullerian Hormone / blood*
  • Cohort Studies
  • Female
  • Gestational Age
  • Humans
  • Maternal-Fetal Exchange / physiology
  • Mothers
  • Polycystic Ovary Syndrome / blood*
  • Polycystic Ovary Syndrome / diagnosis*
  • Pregnancy
  • Pregnancy Trimester, Second / blood*
  • Prenatal Exposure Delayed Effects / blood*
  • Prognosis
  • Prospective Studies
  • Testosterone / blood*


  • Testosterone
  • Anti-Mullerian Hormone