C-C chemokine receptor 1 expression in human hematolymphoid neoplasia

Am J Clin Pathol. 2010 Mar;133(3):473-83. doi: 10.1309/AJCP1TA3FLOQTMHF.


Chemokine receptor 1 (CCR1) is a G protein-coupled receptor that binds to members of the C-C chemokine family. Recently, CCL3 (MIP-1alpha), a high-affinity CCR1 ligand, was identified as part of a model that independently predicts survival in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of chemokine signaling in the pathogenesis of human lymphomas is unclear. In normal human hematopoietic tissues, we found CCR1 expression in intraepithelial B cells of human tonsil and granulocytic/monocytic cells in the bone marrow. Immunohistochemical analysis of 944 cases of hematolymphoid neoplasia identified CCR1 expression in a subset of B- and T-cell lymphomas, plasma cell myeloma, acute myeloid leukemia, and classical Hodgkin lymphoma. CCR1 expression correlated with the non-germinal center subtype of DLBCL but did not predict overall survival in follicular lymphoma. These data suggest that CCR1 may be useful for lymphoma classification and support a role for chemokine signaling in the pathogenesis of hematolymphoid neoplasia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • B-Lymphocytes / metabolism
  • Bone Marrow / metabolism*
  • Chi-Square Distribution
  • Cluster Analysis
  • Granulocytes / metabolism
  • Humans
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute / metabolism*
  • Lymphoma / metabolism*
  • Middle Aged
  • Multiple Myeloma / metabolism*
  • Neoplasm Proteins / metabolism
  • Palatine Tonsil / metabolism*
  • Receptors, CCR1 / metabolism*


  • CCR1 protein, human
  • Neoplasm Proteins
  • Receptors, CCR1