Impact of Lifestyle on Overall Cancer Risk Among Japanese: The Japan Public Health Center-based Prospective Study (JPHC Study)

J Epidemiol. 2010;20(2):90-6. doi: 10.2188/jea.je20090209. Epub 2010 Feb 13.


In Japan, cancer has long been recognized as a major component of the overall pattern of disease. Currently, there is a need to implement practical control measures with specific numerical targets appropriate for the Japanese population. Using data from the Japan Public Health Center-based Prospective Study, the author estimated the impact of major risk factors on overall cancer risk among a Japanese population. These risk factors included tobacco smoking, alcohol drinking, body mass index, history of diabetes, physical activity, and metabolic factors and their aggregates. The results show that tobacco smoking and heavy alcohol drinking were significantly positively associated with overall cancer risk, and that total physical activity was significantly inversely associated with the risk of cancer. Although people with a history of diabetes may be at increased risk of cancer, extreme body mass index and metabolic factors in the aggregate had little impact on overall cancer risk in the Japanese population.

MeSH terms

  • Alcohol Drinking / adverse effects
  • Asian Continental Ancestry Group / psychology*
  • Body Mass Index
  • Diabetes Mellitus
  • Exercise
  • Female
  • Humans
  • Japan / epidemiology
  • Life Style*
  • Male
  • Metabolic Syndrome / complications
  • Neoplasms / epidemiology*
  • Neoplasms / etiology
  • Prospective Studies
  • Public Health
  • Risk Factors
  • Smoking / adverse effects