Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes

Nat Neurosci. 2010 Mar;13(3):333-7. doi: 10.1038/nn.2493. Epub 2010 Feb 14.


Kv4 low voltage-activated A-type potassium channels are widely expressed in excitable cells, where they control action potential firing, dendritic activity and synaptic integration. Kv4 channels exist as a complex that includes K(+) channel-interacting proteins (KChIPs), which contain calcium-binding domains and therefore have the potential to confer calcium dependence on the Kv4 channel. We found that T-type calcium channels and Kv4 channels form a signaling complex in rat that efficiently couples calcium influx to KChIP3 to modulate Kv4 function. This interaction was critical for allowing Kv4 channels to function in the subthreshold membrane potential range to regulate neuronal firing properties. The widespread expression of these channels and accessory proteins indicates that the Cav3-Kv4 signaling complex is important for the function of a wide range of electrically excitable cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Brain / drug effects
  • Brain / physiology
  • Calcium / metabolism
  • Calcium Channels, T-Type / genetics
  • Calcium Channels, T-Type / metabolism*
  • Cell Line
  • Extracellular Space / metabolism
  • Humans
  • In Vitro Techniques
  • Kinetics
  • Kv Channel-Interacting Proteins / metabolism
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Neurons / drug effects
  • Neurons / physiology*
  • Rats
  • Rats, Sprague-Dawley
  • Shal Potassium Channels / metabolism*


  • Calcium Channels, T-Type
  • Kv Channel-Interacting Proteins
  • Shal Potassium Channels
  • Calcium