Fermentation of corn fiber hydrolysate to lactic acid by the moderate thermophile Bacillus coagulans

Biotechnol Lett. 2010 Jun;32(6):823-8. doi: 10.1007/s10529-010-0222-z. Epub 2010 Feb 14.


A strain of Bacillus coagulans that converted mixed sugars of glucose, xylose, and arabinose to L: -lactic acid with 85% yield at 50 degrees C was isolated from composted dairy manure. The strain was tolerant to aldehyde growth inhibitors at 2.5 g furfural/l, 2.5 g 5-hydroxymethylfurfural/l, 2.5 g vanillin/l, and 1.2 g p-hydroxybenzaldehyde/l. In a simultaneous saccharification and fermentation process, the strain converted a dilute-acid hydrolysate of 100 g corn fiber/l to 39 g lactic acid/l in 72 h at 50 degrees C. Because of its inhibitor tolerance and ability to fully utilize pentose sugars, this strain has potential to be developed as a biocatalyst for the conversion of agricultural residues into valuable chemicals.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Bacillus / drug effects
  • Bacillus / isolation & purification
  • Bacillus / metabolism*
  • Cattle
  • Fermentation
  • Lactic Acid / metabolism*
  • Manure / microbiology
  • Zea mays / metabolism*


  • Anti-Bacterial Agents
  • Manure
  • Lactic Acid