Somatic allelic deletion of nm23 in human cancer

Cancer Res. 1991 May 1;51(9):2490-3.

Abstract

Tumor progression to the metastatic phenotype is accompanied in certain cell types by reduced expression of the nm23 gene. We have localized human nm23-H1 to chromosome 17 by somatic cell hybrid analysis. Regional localization in the CEPH database and in situ hybridization is reported. Somatic allelic deletion of nm23-H1 was observed in human breast, renal, colorectal, and lung carcinoma DNA samples, as compared to DNA from matched normal tissues. A homozygous deletion of nm23-H1 was observed in a lymph node metastasis of a colorectal carcinoma, indicating that nm23-H1 can be recessively inactivated. The data identify nm23-H1 as a novel, independent locus for allelic deletion in human cancer, a characteristic shared with previously described suppressor genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Chromosome Deletion*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 17*
  • Humans
  • Male
  • Monomeric GTP-Binding Proteins*
  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Proteins / genetics*
  • Neoplasms / genetics*
  • Nucleoside-Diphosphate Kinase*
  • Proteins / genetics*
  • Transcription Factors*

Substances

  • NM23 Nucleoside Diphosphate Kinases
  • Neoplasm Proteins
  • Proteins
  • Transcription Factors
  • NME1 protein, human
  • Nucleoside-Diphosphate Kinase
  • Monomeric GTP-Binding Proteins