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. 2010;9(1):5.
doi: 10.1186/jbiol197. Epub 2010 Feb 5.

Reprogramming of the non-coding transcriptome during brain development

Saba Valadkhan  1 , Timothy W Nilsen
Affiliations

Reprogramming of the non-coding transcriptome during brain development

Saba Valadkhan et al. J Biol. 2010.

Abstract

A recent global analysis of gene expression during the differentiation of neuronal stem cells to neurons and oligodendrocytes indicates a complex pattern of changes in the expression of both protein-coding transcripts and long non-protein-coding RNAs.

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Figures

Figure 1
Figure 1
Genomic position of lncRNAs may offer clues to their function. The positional relationship of the lncRNAs (thin arrows) compared to the transcript they regulate (thick arrow) is shown. Serrated lines indicate the long distance between the intergenic lncRNAs and the nearest known transcript, which they may or may not regulate. The three major functional mechanisms employed by currently characterized lncRNAs are listed to the right, and the likelihood that each strategy is used is shown by: - (unlikely to be used), + (likely to be used) or ++ (very likely to be used) signs.
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References

    1. ENCODE Project Consortium. Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007;447:799–816. doi: 10.1038/nature05874. - DOI - PMC - PubMed
    1. Mercer TR, Dinger ME, Mattick JS. Long non-coding RNAs: insights into functions. Nat Rev Genet. 2009;10:155–159. doi: 10.1038/nrg2521. - DOI - PubMed
    1. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009;136:629–641. doi: 10.1016/j.cell.2009.02.006. - DOI - PubMed
    1. Wilusz JE, Sunwoo H, Spector DL. Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 2009;23:1494–1504. doi: 10.1101/gad.1800909. - DOI - PMC - PubMed
    1. Taft RJ, Pheasant M, Mattick JS. The relationship between non-protein-coding DNA and eukaryotic complexity. BioEssays. 2007;29:288–299. doi: 10.1002/bies.20544. - DOI - PubMed

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