Growth and aging: a common molecular mechanism

Aging (Albany NY). 2009 Apr 20;1(4):357-62. doi: 10.18632/aging.100040.


It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

Keywords: TOR; aging; growth; mitochondria; rapamycin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / physiology*
  • Animals
  • Biological Evolution*
  • Energy Metabolism
  • Humans
  • Signal Transduction / genetics*
  • Signal Transduction / physiology*