Macronutrient balance and lifespan

Aging (Albany NY). 2009 Oct 22;1(10):875-80. doi: 10.18632/aging.100098.


Dietary restriction (DR) without malnutrition is widely regarded to be a universal mechanism for prolonging lifespan. It is generally believed that the benefits of DR arise from eating fewer calories (termed caloric restriction, CR). Here we argue that, rather than calories, the key determinant of the relationship between diet and longevity is the balance of protein to non-protein energy ingested. This ratio affects not only lifespan, but also total energy intake, metabolism, immunity and the likelihood of developing obesity and associated metabolic disorders. Among various possible mechanisms linking macronutrient balance to lifespan, the nexus between the TOR and AMPK signaling pathways is emerging as a central coordinator.

Keywords: AMPK; TOR; caloric restriction; dietary restriction; geometric framework; nutrient balance; protein.

MeSH terms

  • AMP-Activated Protein Kinases / physiology
  • Aging / physiology*
  • Animals
  • Diet, Protein-Restricted
  • Diet, Reducing
  • Drosophila Proteins / physiology
  • Drosophila melanogaster / physiology*
  • Female
  • Food*
  • Hemostasis / physiology*
  • Longevity / physiology*
  • Male
  • Protein Kinases / physiology
  • Signal Transduction / physiology
  • TOR Serine-Threonine Kinases


  • Drosophila Proteins
  • Protein Kinases
  • target of rapamycin protein, Drosophila
  • AMPKalpha protein, Drosophila
  • TOR Serine-Threonine Kinases
  • AMP-Activated Protein Kinases