Clinical, ultrasonographic and radiographic features of proximal suspensory desmitis in the forelimb and the hindlimb are described. Acute cases may present with slight, localised, oedematous swelling, heat, distension of the medial palmar (plantar) vein and/or pain, whereas chronic cases or those rested immediately after onset of lameness usually have no detectable clinical signs suggestive of the source of pain. In these cases local analgesia is required to identify pain in the proximal metacarpal (metatarsal) region. Transverse ultrasonographic images of the suspensory ligament usually yield the most information and a variety of abnormalities of the proximal suspensory ligament have been identified including i) enlargement ii) poor definition of one or more of the margins of the suspensory ligament, especially dorsally iii) a well circumscribed, central hypoechoic area iv) one or more poorly defined hypoechoic areas, central or more peripheral v) a larger area of diffuse decrease in echogenicity (such lesions were seen most commonly in the hindlimb and appeared to warrant a more guarded prognosis than focal lesions). Radiographic abnormalities were identified in hindlimbs more often than in forelimbs and were usually seen in a dorsopalmar (dorsoplantar) view, and/or a lateromedial projection. Radiographic abnormalities included sclerosis of the trabeculae, a change in orientation of the trabeculae and entheseophyte formation. The most extensive radiographic abnormalities were seen together with an ultrasonographic type v lesion. The prognosis for return to full athletic function and sustained future soundness was better for forelimbs than hindlimbs, especially if the lesion, identified ultrasonographically, resolved.