Treatment of cellulite: Part I. Pathophysiology

J Am Acad Dermatol. 2010 Mar;62(3):361-70; quiz 371-2. doi: 10.1016/j.jaad.2009.10.042.


Cellulite is a topographic skin change that is nearly ubiquitous in postpubertal women. Treatment remains elusive. The various treatments currently available are only partially or temporarily effective. Newer therapeutic modalities continue to evolve without much understanding of the complex nature of cellulite. The successful treatment of cellulite will ultimately depend upon our understanding of the pathophysiology of cellulite adipose tissue. Part I of this two-part series on cellulite reviews how the concept and perception of cellulite has evolved over time and its proposed etiologies. The article also focuses on the physiology of human adipose tissue, particularly regarding cellulite.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / pathology
  • Adipose Tissue / physiopathology*
  • Adipose Tissue, Brown / physiology
  • Adipose Tissue, White / physiology
  • Body Mass Index
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Obesity / pathology
  • Obesity / physiopathology*
  • Sex Factors
  • Subcutaneous Fat / pathology
  • Subcutaneous Fat / physiopathology