Genetics of addictions

Psychiatr Clin North Am. 2010 Mar;33(1):107-24. doi: 10.1016/j.psc.2009.10.003.


Addictions include a group of common, heritable psychiatric illnesses that have multiple psychiatric and medical comorbidities. Robust genetic associations have been found for alcohol dependence, nicotine dependence, and cocaine dependence. Common genetic associations have been found between alcohol dependence and aerodigestive cancers and between nicotine dependence and lung disease. These associations highlight the importance of understanding the genetics of substance dependence in the context of its multiple medical and psychiatric comorbidities.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Comorbidity
  • Gene Expression / genetics
  • Genome-Wide Association Study
  • Humans
  • Mental Disorders / epidemiology
  • Mental Disorders / psychology
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / genetics*