Imaging the human medial temporal lobe with high-resolution fMRI

Neuron. 2010 Feb 11;65(3):298-308. doi: 10.1016/j.neuron.2009.12.022.


High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain Mapping*
  • Carbamide Peroxide
  • Drug Combinations
  • Hippocampus / blood supply
  • Humans
  • Image Processing, Computer-Assisted / methods
  • Magnetic Resonance Imaging*
  • Nerve Net / blood supply
  • Neural Pathways / blood supply
  • Peroxides / blood*
  • Temporal Lobe / blood supply*
  • Urea / analogs & derivatives*
  • Urea / blood


  • Drug Combinations
  • Peroxides
  • Carbamide Peroxide
  • Urea