Werner helicase wings DNA binding

Structure. 2010 Feb 10;18(2):149-51. doi: 10.1016/j.str.2010.01.007.

Abstract

In this issue of Structure, Kitano et al. describe the structure of the DNA-bound winged-helix domain from the Werner helicase. This structure of a RecQ/DNA complex offers insights into the DNA-unwinding mechanisms of RecQ family helicases.

Publication types

  • News
  • Comment

MeSH terms

  • DNA* / chemistry
  • DNA* / metabolism
  • Exodeoxyribonucleases / chemistry*
  • Exodeoxyribonucleases / genetics
  • Exodeoxyribonucleases / metabolism*
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Models, Molecular
  • Protein Structure, Tertiary
  • RecQ Helicases / chemistry*
  • RecQ Helicases / genetics
  • RecQ Helicases / metabolism*
  • Werner Syndrome / enzymology*
  • Werner Syndrome Helicase

Substances

  • Isoenzymes
  • DNA
  • Exodeoxyribonucleases
  • RecQ Helicases
  • WRN protein, human
  • Werner Syndrome Helicase