The BCL-2 family reunion

Mol Cell. 2010 Feb 12;37(3):299-310. doi: 10.1016/j.molcel.2010.01.025.


B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Apoptosis
  • Autophagy
  • Endoplasmic Reticulum / metabolism
  • Mitochondrial Membranes / metabolism
  • Mitochondrial Membranes / ultrastructure
  • Models, Biological
  • Molecular Sequence Data
  • Multigene Family
  • Permeability
  • Proto-Oncogene Proteins c-bcl-2 / chemistry
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / physiology*
  • Sequence Alignment
  • Signal Transduction


  • Proto-Oncogene Proteins c-bcl-2