Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link

Cancer Cell. 2010 Feb 17;17(2):115-7. doi: 10.1016/j.ccr.2010.01.018.


There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.