Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin

Kunchithapatham Janakiraman; Rajappan Manavalan

doi:10.4314/ajtcam.v5i3.31281

Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin

Afr J Tradit Complement Altern Med. 2008 Apr 10;5(3):257-62. doi: 10.4314/ajtcam.v5i3.31281.

Authors

Kunchithapatham Janakiraman¹, Rajappan Manavalan

Affiliation

¹ Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India. janakiraman_k06@yahoo.co.in

Abstract

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.

Keywords: Ampicillin; Bioavailability; Norfloxacin; Phamacokinetics; Piper nigrum; Piperine.