Inflammation, innate immunity and blood coagulation

Hamostaseologie. 2010 Jan;30(1):5-6, 8-9.

Abstract

Inflammation drives arterial, venous and microvascular thrombosis. Chronic inflammation contributes to arterial thrombotic complications, whereas acute inflammation drives venous thrombosis and microvascular thrombosis. Mechanistically, inflammation modulates thrombotic responses by upregulating procoagulants, downregulating anticoagulants and suppressing fibrinolysis. The inflammatory response can also result in cell apoptosis or necrosis. Products released from the dead cells, particularly histones, propagate further inflammation, tissue death and organ failure. Inhibition of histone mediated cytotoxicity appears to be a new mechanism for protecting against this deadly cascade.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticoagulants / pharmacology
  • Blood Coagulation / immunology
  • Blood Coagulation / physiology*
  • Cell Death
  • Fibrinolysis / physiology
  • Histones / antagonists & inhibitors
  • Humans
  • Immunity, Innate*
  • Inflammation / complications
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation / physiopathology*
  • Platelet Aggregation Inhibitors / pharmacology
  • Thrombosis / etiology
  • Thrombosis / physiopathology

Substances

  • Anticoagulants
  • Histones
  • Platelet Aggregation Inhibitors