A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp

Arch Pharm Res. 2009 Dec;32(12):1695-8. doi: 10.1007/s12272-009-2205-y. Epub 2010 Feb 17.

Abstract

One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Chromatography, Ion Exchange
  • Chromatography, Thin Layer
  • Coloring Agents
  • Humans
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Porifera / chemistry*
  • Spectrophotometry, Infrared
  • Sterols / chemistry*
  • Sterols / isolation & purification
  • Sterols / pharmacology
  • Tetrazolium Salts
  • Thiazoles
  • Vietnam

Substances

  • Antineoplastic Agents
  • Coloring Agents
  • Indicators and Reagents
  • Sterols
  • Tetrazolium Salts
  • Thiazoles
  • aragusteroketal B
  • thiazolyl blue