Gold nanoparticle self-similar chain structure organized by DNA origami

J Am Chem Soc. 2010 Mar 17;132(10):3248-9. doi: 10.1021/ja9101198.


Here we demonstrate Au nanoparticle self-similar chain structure organized by triangle DNA origami with well-controlled orientation and <10 nm spacing. We show for the first time that a large DNA complex (origami) and multiple AuNP conjugates can be well-assembled and purified with reliable yields. The assembled structure could be used to generate high local-field enhancement. The same method can be used to precisely localize multiple components on a DNA template for potential applications in nanophotonic, nanomagnetic, and nanoelectronic devices.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • DNA / chemistry*
  • Electrophoresis, Agar Gel
  • Gold / chemistry*
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Scanning
  • Nanotechnology / methods
  • Nucleic Acid Conformation
  • Spectrophotometry, Ultraviolet


  • Gold
  • DNA