A model-based meta-analysis of the effect of latanoprost chronotherapy on the circadian intraocular pressure of patients with glaucoma or ocular hypertension

Clin Pharmacol Ther. 2010 Apr;87(4):421-5. doi: 10.1038/clpt.2009.306. Epub 2010 Feb 17.


Several reports have demonstrated that the efficacy of latanoprost is influenced by the time of dosing. This model-based meta-analysis validates previous findings that evening dosing is superior to morning dosing and predicts the optimal time for dosing, based on the quantitative assessment of baseline and latanoprost-treated 24-h circadian intraocular pressure (IOP) curves. The results confirm the importance of the time of dosing as a factor that influences the extent of reduction in IOP and underline the need to take this factor into consideration in the design of glaucoma trials and therapy.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antihypertensive Agents / administration & dosage*
  • Antihypertensive Agents / pharmacology
  • Circadian Rhythm
  • Drug Administration Schedule
  • Glaucoma, Open-Angle / drug therapy
  • Glaucoma, Open-Angle / physiopathology
  • Humans
  • Intraocular Pressure / drug effects*
  • Latanoprost
  • Ocular Hypertension / drug therapy
  • Ocular Hypertension / physiopathology
  • Prostaglandins F, Synthetic / administration & dosage*
  • Prostaglandins F, Synthetic / pharmacology


  • Antihypertensive Agents
  • Prostaglandins F, Synthetic
  • Latanoprost