Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia cells

Leukemia. 2010 Apr;24(4):851-5. doi: 10.1038/leu.2010.3. Epub 2010 Feb 18.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Biphenyl Compounds / pharmacology
  • Caspase Inhibitors
  • Caspases / metabolism
  • Drug Synergism
  • Humans
  • Immunoblotting
  • Leukemia / drug therapy
  • Leukemia / metabolism
  • Leukemia / pathology*
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Nitrophenols / pharmacology
  • Nucleosides / pharmacology*
  • Piperazines / pharmacology
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Pyrimidines / pharmacology*
  • Sulfonamides / pharmacology
  • Tumor Cells, Cultured

Substances

  • 4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide
  • ABT-737
  • Antineoplastic Agents
  • Biphenyl Compounds
  • Caspase Inhibitors
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Nitrophenols
  • Nucleosides
  • Piperazines
  • Proto-Oncogene Proteins c-bcl-2
  • Pyrimidines
  • Sulfonamides
  • Caspases