Comparative effect of body mass index on response to asthma controller therapy

Allergy Asthma Proc. Jan-Feb 2010;31(1):20-5. doi: 10.2500/aap.2010.31.3307.

Abstract

Increases in body mass index (BMI) are reported to influence asthma severity and response to treatment. This analysis was designed to explore whether increasing BMI altered the comparative response to treatment with either fluticasone propionate (FP) or montelukast. Two double-blind, randomized, parallel-group trials of 12-weeks duration comparing FP, 88 micrograms, twice daily or montelukast, 10 mg, daily were evaluated. Subjects with mild-moderate persistent asthma were retrospectively stratified by BMI of <20 kg/m(2) (underweight), 20-24.9 kg/m(2) (normal weight), 25-29.9 kg/m(2) (overweight), and > or =30 kg/m(2) (obese). Outcomes included mean changes in forced expiratory volume in 1 second (FEV(1)) and morning peak flow, daily albuterol use, and daily symptom scores. There were 1052 subjects evenly distributed between FP and montelukast by baseline parameters, including BMI. FP was statistically superior to montelukast for all BMI categories of normal, overweight, and obese subjects for FEV(1) (p < 0.008), morning peak flow (p < 0.002), albuterol use (p < 0.02), and symptom scores (p < 0.05). FP produced a significantly greater clinical response for normal, overweight, and obese subjects compared with montelukast. Irrespective of BMI, FP appears to be the more effective asthma controller therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetates* / administration & dosage
  • Acetates* / therapeutic use
  • Administration, Inhalation
  • Adolescent
  • Adult
  • Androstadienes* / administration & dosage
  • Androstadienes* / therapeutic use
  • Anti-Asthmatic Agents* / administration & dosage
  • Anti-Asthmatic Agents* / therapeutic use
  • Asthma / complications*
  • Asthma / drug therapy*
  • Asthma / physiopathology
  • Asthma / prevention & control
  • Body Mass Index*
  • Double-Blind Method
  • Drug Administration Schedule
  • Female
  • Fluticasone
  • Forced Expiratory Volume
  • Humans
  • Male
  • Middle Aged
  • Obesity / complications
  • Obesity / drug therapy
  • Overweight / complications
  • Overweight / drug therapy
  • Quinolines* / administration & dosage
  • Quinolines* / therapeutic use
  • Randomized Controlled Trials as Topic
  • Treatment Outcome
  • Young Adult

Substances

  • Acetates
  • Androstadienes
  • Anti-Asthmatic Agents
  • Quinolines
  • Fluticasone
  • montelukast