Mammalian recombination hot spots: properties, control and evolution

Nat Rev Genet. 2010 Mar;11(3):221-33. doi: 10.1038/nrg2712.


Recombination, together with mutation, generates the raw material of evolution, is essential for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to construct genome-scale, high-resolution recombination maps and new molecular techniques for analysing recombination products have substantially furthered our understanding of this important biological phenomenon in humans and mice: from describing the properties of recombination hot spots in male and female meiosis to the recombination landscape along chromosomes. This progress has been accompanied by the identification of trans-acting systems that regulate the location and relative activity of individual hot spots.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Crossing Over, Genetic
  • Evolution, Molecular
  • Female
  • Gene Conversion
  • Genetic Variation
  • Humans
  • Male
  • Meiosis / genetics
  • Mice
  • Models, Genetic
  • Mutation
  • Polymorphism, Single Nucleotide
  • Recombination, Genetic*
  • Selection, Genetic
  • Sex Characteristics
  • Spermatozoa / metabolism