Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer

Nat Rev Cancer. 2010 Mar;10(3):213-21. doi: 10.1038/nrc2804. Epub 2010 Feb 19.


The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • Cell- and Tissue-Based Therapy / history
  • Hematopoietic Stem Cell Transplantation / history*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immunotherapy / history*
  • Neoplasms / immunology
  • Neoplasms / physiopathology
  • Neoplasms / therapy*
  • Precision Medicine / history*
  • Transplantation, Homologous / history