Clinical monitoring of systemic hemodynamics in critically ill newborns

Early Hum Dev. 2010 Mar;86(3):137-41. doi: 10.1016/j.earlhumdev.2010.01.031. Epub 2010 Feb 20.


Circulatory failure is a major cause of mortality and morbidity in critically ill newborn infants. Since objective measurement of systemic blood flow remains very challenging, neonatal hemodynamics is usually assessed by the interpretation of various clinical and biochemical parameters. An overview is given about the predictive value of the most used indicators of circulatory failure, which are blood pressure, heart rate, urine output, capillary refill time, serum lactate concentration, central-peripheral temperature difference, pH, standard base excess, central venous oxygen saturation and colour.

MeSH terms

  • Acid-Base Equilibrium / physiology
  • Blood Circulation / physiology*
  • Blood Pressure / physiology
  • Body Temperature / physiology
  • Critical Illness*
  • Heart Rate / physiology
  • Hemodynamics / physiology*
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / physiopathology*
  • Lactic Acid / blood
  • Monitoring, Physiologic / methods*
  • Practice Guidelines as Topic
  • Predictive Value of Tests
  • Urine / physiology


  • Lactic Acid